Cisplatin induced apoptosis

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August undefined, 2024

WebTo study the mechanism of apoptosis induced by cisplatin in vitro in HeLa cells cervical cancer cell line. The inhibitory effect of cisplatin on HeLa cell growth was analyzed by … WebRenal tubular epithelial cell apoptosis is the main mechanism of cisplatin-induced acute kidney injury. The role of microRNAs (miRNAs) in the apoptosis of renal tubular epithelial cells has...

Current Oncology Free Full-Text Blockade of ALDH in Cisplatin ...

WebDec 8, 2024 · We observed that combined treatment with mdivi-1 and cisplatin induced downregulation of c-FLIP expression (Figure 2 C). c-FLIP is a major anti-apoptotic protein and is involved in death receptor-mediated apoptosis and chemotherapeutic drug resistance in cancer cells . To investigate the role of c-FLIP downregulation in combined … WebMar 9, 2024 · Lentinan can alleviate cisplatin-induced apoptosis of HK-2 human kidney proximal tubular cells and disrupt renal function in mice. The mechanism is related to the activation of the NRF2-ARE signaling pathway and decrease in intracellular ROS. Moreover, lentinan also inhibits the proliferation of HeLa and A549 cells . how did the creator of roblox die

Silence of URI in gastric cancer cells promotes cisplatin-induced …

WebJul 1, 1999 · Cisplatin-induced apoptosis proceeds by caspase-3-dependent and -independent pathways in cisplatin-resistant and -sensitive human ovarian cancer cell lines. We have assessed in detail the effect of cisplatin-activated programmed cell death … WebApr 1, 2016 · By using two pairs of genetically matched cisplatin-sensitive and cisplatin-resistant ovarian cancer cell lines, we tested the hypothesis that downregulating hypoxia-inducible factor-1 (HIF-1), which regulates metabolic enzymes involved in glycolysis, is a promising strategy for overcoming cisplatin resistance of human ovarian cancer cells. WebThe role of intra- and extracellular pH in apoptosis induction was investigated. Activation of caspase-3 and DNA ladder formation were used to monitor the apoptotic response. … how many starters are there in pokemon 2022

Mechanisms of Cisplatin-Induced Apoptosis and of …

Requirement for ERK Activation in Cisplatin-induced …

WebCisplatin-induced nuclear DNA (nDNA) damage in dorsal root ganglion (DRG) neurons has been thoroughly investigated. Cisplatin covalently binds to nuclear DNA (nDNA) inducing DNA damage and apoptosis. Cisplatin-induced DNA damage up-regulates p53 and induces cell cycle changes in DRG neurons. WebCisplatin (cis-diamminedichloroplatinum; CDDP) 1 is a potent inducer of growth arrest and/or apoptosis in most cell types and is among the most effective and widely used chemotherapeutic agents employed for … how did the crack epidemic startWebOct 15, 2001 · Recently, apoptosis has been recognized as an important mechanism of cell death mediating the antitumor effect of cisplatin. This study was undertaken to examine the mechanisms of cell death induced by cisplatin in M-1 cells, which were derived from the outer cortical collecting duct cells of SV40 transgenic mice. how many star trek movies are there

"WebSep 8, 2016 · To assess cisplatin-induced hair cell apoptosis, we used immunofluorescence staining of cleaved caspase 3, a common executor in the apoptotic pathway. 23 Cochlear explants were transfected with ... " - Cisplatin induced apoptosis

Cisplatin induced apoptosis

WebThe chemotherapeutic cisplatin causes renal dysfunction and renal proximal tubular cell (RPTC) apoptosis. The goal of these studies was to examine the role of p53, caspase 3, 8, and 9, and mitochondria in the signaling of cisplatin-induced apoptosis. Cisplatin (50 microM) produced time-dependent apo … WebMay 1, 2001 · Cisplatin is one of the platinum-based drugs which act by crosslinking with DNA and thus interfere with cell division triggering apoptosis (Pruefer et al., 2008). In fact, Cisplatin causes cell ...

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WebApr 14, 2024 · Since HK-2-cells-generated-Abs, both by cisplatin or upon UV light exposure, can induce apoptosis in HK-2 cells, the purpose of this work was to study their metabolome and therein find the molecular features which help us to unravel the mechanisms of that phenomenon. WebNov 7, 2024 · Cisplatin binds to DNA and induces DNA-damage culminating in mitochondria-mediated apoptosis. Interestingly, mitochondrial DNA is critically affected …

WebThe chemotherapeutic drug cisplatin elicits cytotoxicity causing renal tubular cell death, but its executing mechanisms of action are versatile and elusive. Here, we show that cisplatin induces renal tubular cell apoptosis and ferroptosis by … WebAim: To investigate the synergetic effect and the mechanism of antitumor action of the antibiotic lidamycin in combination with cisplatin in vitro. Methods: Cytotoxicity of the drugs was measured by clonogenic assay. Chromatin condensation was observed by co-staining with fluorescent dyes, Hoechst 33342 and propidium iodide. Apoptotic sub-G1 was …

WebSep 1, 2024 · By contrast, cisplatin-induced apoptosis and necroptosis were inhibited by treatment with Fer-1. Moreover, deferoxamine, an iron chelator, also inhibited CIN, with a decrease in the expression of COX-2 and 4-HNE. Conclusion. Ferroptosis is involved in the pathogenesis of CIN and might be used as a new preventive target for CIN. WebCisplatin is the most important and efficacious chemotherapeutic agent for the treatment of advanced gastric cancer. Cisplatin forms inter- and intrastrand crosslinked DNA adducts …

WebOn the contrary, coadministration of 4-PBA reduces the expression of GRP78 and CHOP and enhances apoptosis in cisplatin-treated osteosarcoma cell lines, indicating that cisplatin-induced ER stress protects cell from apoptosis in these cell lines .

WebThis study investigated non-targeted metabolomic analysis on ABs and medium from apoptotic HK-2 cells induced with cisplatin or exposure to UV light. ... We did not mean that these differences will result in differences in the extension of apoptosis induced by ABs because we knew from our previous work published in Biochimica et Biophysica … how did the creeslough explosion happenWebJul 1, 1999 · The results thus far suggest that CP70 and C30 cells initiate apoptosis via a caspase-3-dependent pathway. However, even in the absence of caspase-3 activation, A2780 cells do exhibit some morphological characteristics of cisplatin-induced apoptosis, including a subset of the biochemical features of PCD. how did the creator of yugioh die how did the crash of 1929 happenWebVarious recent studies have investigated (GLP-1R) role in cardiovascular diseases due to antiapoptotic and antioxidant effects. The current study aimed to investigate the curative … how did the cree huntWebCisplatin (cis-diamminedichloroplatinum (II), DDP) is an antineoplastic agent widely used in the treatment of solid tumors because of its extensive cytotoxic activity. However, the main limiting side effect of DDP use is nephrotoxicity, a rapid deterioration in kidney function due to toxic chemicals. Several studies have shown that epigenetic processes are involved in … how did the cree liveWebCisplatin-induced early-onset ototoxicity is linked to hearing loss. The mechanism by which cisplatin causes ototoxicity remains unclear. The purpose of this study was to identify … how many star trek movies with chrisWebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different … how many star trek enterprise ships