Cyclin e overexpression
WebApr 15, 2024 · Lung cancer is the most prevalent malignancy and the first leading cause of cancer deaths across the globe and accounting for approximately 18% of all cancer deaths in China [1, 2].Non-small cell lung cancer (NSCLC), the major type of lung cancer, represents > 80% of all lung carcinoma cases [].Most patients diagnosed in the … Cyclin E overexpression can lead to G1 shortening, decrease in cell size or loss of serum requirement for proliferation. Dysregulation of cyclin E occurs in 18-22% of the breast cancers. Cyclin E is a prognostic marker in breast cancer, its altered expression increased with the increasing stage and grade of the … See more Cyclin E is a member of the cyclin family. Cyclin E binds to G1 phase Cdk2, which is required for the transition from G1 to S phase of the cell cycle that determines initiation of DNA duplication. The Cyclin E/CDK2 complex See more Like all cyclin family members, cyclin E forms a complex with cyclin-dependent kinase (CDK2). Cyclin E/CDK2 regulates multiple cellular processes by phosphorylating numerous downstream proteins. Cyclin E/CDK2 … See more Over-expression of cyclin E correlates with tumorigenesis. It is involved in various types of cancers, including breast, colon, bladder, skin and lung cancer. DNA copy-number … See more • Cyclin+E at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more
Cyclin e overexpression
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WebApr 7, 2024 · The inhibitory effect of 1,6-HD on cyclin A1 is mainly through transcriptional regulation because proteasome inhibitors fail to rescue its expression. Furthermore, overexpression of cyclin A1 in HUVECs largely rescues the dysregulated tube formation upon 1,6-HD treatment. WebFeb 16, 2024 · Cyclin E/CDK2 drives cell cycle progression from G1 to S phase. Despite the toxicity of cyclin E overproduction in mammalian cells, the cyclin E gene is overexpressed in some cancers. To further understand how cells can tolerate high cyclin E, we characterized non-transformed epithelial cells subjected to chronic cyclin E …
WebNov 1, 2024 · Cyclin E (CCNE) overexpression has been implicated in trastuzumab resistance. We sought to uncover a potential mechanism for this trastuzumab resistance and focused on a model of CCNE overexpressing HER2+ breast cancer and noncanonical phosphorylation of the TGF-β signaling protein, SMAD3. WebCyclin E is an evolutionarily conserved protein whose essential function is to promote the cell cycle transition from G 1 to S phase (Knoblich et al. 1994; Ohtsubo et al. …
WebMar 29, 2024 · The overexpression of cyclin E positively correlated with the decreasing degree of tumor differentiation, implicating a role for cyclin E in the promotion of tumorigenesis. Cyclin E and cyclin D1 expression distinguishes non-BRCA1/2 tumors from both sporadic and BRCA1- and BRCA2-associated tumors and may reflect different … WebDec 15, 2024 · Cyclin E overexpression (i) is enriched in TNBCs with high recurrence rates, (ii) sensitizes TNBC cell lines and PDX models to AZD1775, (iii) leads to CDK2 …
WebJul 8, 2003 · Cyclin E, the regulatory component of the cyclin E/cyclin-dependent kinase (CDK) complex, is required for proliferation and overexpression of this cyclin is …
WebApr 15, 2024 · Lung cancer is the most prevalent malignancy and the first leading cause of cancer deaths across the globe and accounting for approximately 18% of all cancer … graphite on periodic tableWebA positive correlation between the cyclin E expression and proliferative activity of tumor cells was found (r = 0.896; P < 0.0001). Kaplan-Meier analysis showed that shorter … graphite or aluminium badminton racketWebCyclin D1’s role in the control of cell cycle pro-gression and the location of the cyclin D1 gene at chromosome 11q13, a locus that is frequently ampli-fied in breast and other … graphite operating temperatureWebMar 30, 2015 · Elevated cyclin E1 is associated with aggressive disease in a variety of human tumors including breast, for which it is one of the most reliable independent prognostic markers [ 17, 18 ]. In breast cancer, cyclin E1 is overexpressed in 30% of patients, including overexpression of both the full length (50 kDa) and several LMW … chisesbows.comWebMar 3, 2003 · Cyclin E protein accumulation was found in 48 different tumour types. The use of TMA technology has enabled us to expand considerably our knowledge of cyclin … chi set in stone flat ironWebAug 17, 2015 · Cyclin E overexpression correlated with poor overall survival in several tumor types including breast, ovarian, lung and pancreatic cancer. 3, 4 The low … chise theronWebFeb 28, 2024 · These results underscored the utility of the cyclin E/CDK2 complex as a novel target for treatment. Because IBC cell lines were highly sensitive to the CDK2 … chiset man